La Plata is largely a residential community with some residents working for the Charles County government, while others commute to the Washington, D.C. and Baltimore areas for work, including to Andrews Air Force Base and Naval Air Station Patuxent River. The town is experiencing a transformation into a thriving business and commercial center. La Plata has county offices, the University of Maryland Charles Regional Medical Center, the main campus of the College of Southern Maryland, a community theater (Port Tobacco Players), a large outdoor athletic complex, nursing homes, the La Plata Train Station Museum, and a host of stores, churches, and restaurants, in addition to a twice-weekly farmers' market.

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